BOTHELL, Wash. and VANCOUVER, British Columbia, March. 6, 2018 – – Achieve Life Sciences, Inc. (NASDAQ: ACHV), today announced that the World Conference on Tobacco or Health (WCTOH) will be holding a symposium on cytisine research at this year’s annual conference, March 7-9th in Cape Town, South Africa.

The cytisine symposium titled “Is a Globally Affordable Medication to Treat Tobacco Dependence Achievable? The Case of Cytisine.” will be held on Friday, March 9th at 7:45am. Nancy Rigotti, MD, Professor of Medicine, Harvard Medical School and Director, Tobacco Research and Treatment Center, at Massachusetts General Hospital will chair the symposium. Further to Achieve’s collaboration with the National Institutes of Health (NIH) to advance cytisine research, Dr. David Shurtleff, PhD, Acting Director at the NIH, National Center for Complementary and Integrative Health, will be presenting “An Overview of the Safety Assessment for Regulatory Approval of Cytisine in the U.S.”

Dr. Anthony Clarke, PhD, Chief Scientific Officer of Achieve commented, “Significant clinical development progress has been made recently with completion of a Phase I/II trial. Achieve is focused on commencing Phase 3 clinical trials in mid-2018 and appreciates the contributions from the scientific community in aiding the regulatory approval process for cytisine as a cost-effective smoking cessation treatment.”

Two Phase 3 clinical trials of cytisine have been successfully completed in over 2,000 patients. The TASC Phase 3 trial was a 740 patient, double-blind placebo controlled trial conducted by University College London. The CASCAID trial was a 1,310 patient, single-blind trial comparing cytisine to nicotine replacement therapy. Both trials were published in the New England Journal of Medicine in December 2011 and December 2014 respectively.

About Achieve and Cytisine
Achieve’s focus is to address the global smoking health epidemic through the development and commercialization of cytisine. Tobacco use is currently the leading cause of preventable death and is responsible for nearly six million deaths annually worldwide[1]. It is estimated that 28.6% of all cancer deaths in the U.S. are attributable to cigarette smoking[2].

Achieve is developing cytisine as a smoking cessation aid. Cytisine is a plant-based alkaloid with a high binding affinity to the nicotinic acetylcholine receptor. It is an established smoking cessation treatment that has been approved and marketed in Central and Eastern Europe for more than 15 years. It is estimated that over 20 million people have used cytisine to help combat nicotine addiction, including approximately 2,000 patients in Phase 3 clinical trials conducted in Europe and New Zealand. Achieve’s focus is to address the global smoking health epidemic, which is currently the leading cause of preventable death and is responsible for nearly six million people losing their lives annually worldwide. Discussions have been held with FDA and a