SEATTLE, Wash. and VANCOUVER, British Columbia, Sept. 6, 2018 – – Achieve Life Sciences, Inc. (NASDAQ: ACHV), today announced that cytisine data will be presented at the Society for Research on Nicotine and Tobacco Europe (SRNT-E) Annual Conference , September 6-8th in Munich, Germany.
The presentations include a review of cytisine’s safety profile and an overview of Achieve’s upcoming Phase 2b study, planned to initiate later this year. Both presentations will be included in the Pharmacotherapy poster session on Friday, Sept. 7th at 2pm local time.
“This conference provides an excellent opportunity to update the scientific community on the progress we continue to make in advancing the global availability of cytisine,” commented Dr. Cindy Jacobs, MD, PhD, Chief Medical Officer of Achieve. “Our Phase 2b trial, scheduled to commence in the coming months, will further clarify the optimal cytisine dosing schedule and compliance measures to inform our development plans going forward.”
Two, investigator-sponsored Phase 3 clinical trials of cytisine were successfully completed in over 2,000 patients. The TASC Phase 3 trial was a 740 patient, double-blind placebo controlled trial conducted by University College London. The CASCAID trial was a 1,310 patient, single-blind trial comparing cytisine to nicotine replacement therapy. Both trials were published in the New England Journal of Medicine in December 2011 and December 2014 respectively. Achieve is working closely with the smoking cessation community and regulatory agencies to advance the global availability of cytisine.
About Achieve & Cytisine
Achieve’s focus is to address the global smoking health epidemic through the development and commercialization of cytisine. Tobacco use is currently the leading cause of preventable death and is responsible for nearly six million deaths annually worldwide1. It is estimated that 28.6% of all cancer deaths in the U.S. are attributable to cigarette smoking2.
Cytisine is a plant-based alkaloid with a high binding affinity to the nicotinic acetylcholine receptor. Two prior, large-scale Phase 3 clinical studies of cytisine, with favorable outcomes, have been successfully completed in over 2,000 patients. The TASC trial was a 740 patient, double-blind, placebo controlled trial conceived by Professor Robert West at University College London and funded by the U.K. National Prevention Research Initiative. The CASCAID trial was a 1,310 patient, single-blind, non-inferiority trial comparing cytisine to nicotine replacement therapy (NRT). The CASCAID trial was conceived by Dr. Natalie Walker, Nat