Cytisine Demonstrated Superior Abstinence Rates Compared to Nicotine Replacement Therapy

SEATTLE, Wash. and VANCOUVER, British Columbia, Sept. 18, 2018 — Achieve Life Sciences, Inc. (NASDAQ: ACHV), a clinical-stage pharmaceutical company committed to the global development and commercialization of cytisine for smoking cessation, today announced the publication of new cytisine data from an independent observational study in the International Journal of Drug Policy.

The observational study compared the effectiveness of cytisine and nicotine replacement therapy (NRT) as an aid to smoking cessation in the Russian Federation. Evaluation of 301 subjects who had used either cytisine or NRT determined that smokers in the cytisine group were approximately three times more likely to achieve 90-days abstinence compared to those who attempted to quit with NRT (p=0.011). As demonstrated in prior cytisine studies, the highest abstinence rates were observed in subjects who also received smoking cessation behavioral support and counseling. Cytisine was found to be well tolerated. The authors concluded the findings support previous trial evidence indicating that cytisine is superior to NRT for achieving short- and long-term abstinence and should be considered a first-line pharmacologic treatment for smoking cessation.

Rick Stewart, Chairman and Chief Executive Officer of Achieve Life Sciences commented, “These data provide further real-world evidence on the important role cytisine can play in helping smokers quit. Cytisine has been commercially available in numerous countries in Central and Eastern Europe for decades and our mission is to make it a globally available treatment option for people battling nicotine addiction.”

The full article “The effectiveness of Cytisine versus Nicotine Replacement Treatment for Smoking cessation in the Russian Federation” can be accessed by visiting https://www.ijdp.org/article/S0955-3959(18)30161-0/fulltext.

About the Study
Study data were obtained from the 2009 Russian Global Adult Tobacco Survey of more than 11,000 individuals. The observational study utilized cross-sectional data to compare self-reported 30-day and 90-day smoking abstinence rates of smokers who used either cytisine or NR