Whether present in electronic or combustible cigarettes, nicotine is a highly addictive substance. Dr Cindy Jacobs, chief medical officer of Achieve Life Sciences discusses the potential of cytisinicline therapy for smoking cessation.
Although e-cigarettes are considered a less dangerous alternative to combustible cigarettes, they can still result in, or sustain, nicotine addiction, for which the long-term safety issues and associated health risks are unknown.
A recent study showed that current nicotine e-cigarette users who were ex-smokers remained nicotine dependent and had higher nicotine dependence scores if they used e-cigarettes for a longer period of time or if they used more advanced nicotine e-cigarettes (related to size, battery powered, controls, etc.). These results underscored the role that e-cigarettes play in prolonging nicotine use and dependence. Despite the large and growing population of e-cigarette users, there are no nicotine cessation therapies specifically designed to support those who wish to quit e-cigarettes.
E-cigarettes can reduce or eliminate exposure to many of the toxic chemicals present in combustible cigarette smoke and are therefore potentially beneficial in reducing health risks in smokers when used as a replacement for their combustible counterpart. However, despite this potential benefit, e-cigarettes continue to deliver nicotine and are therefore not without their own health risks. Recent and ongoing studies on the health effects of nicotine containing e-cigarettes show correlations with cardiovascular disease, irreversible lung damage and respiratory disease including emphysema, chronic obstructive pulmonary disease, chronic bronchitis, and asthma.
Despite these health concerns, the use of e-cigarettes and nicotine