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Join us in redefining the future of nicotine dependence

We are a late-stage specialty pharmaceutical company dedicated to tackling the global nicotine dependence epidemic by advancing cytisinicline.

In June 2025, we submitted a New Drug Application to the FDA for cytisinicline as a treatment of nicotine dependence for smoking cessation in adults, based on two successfully completed Phase 3 studies and its fully enrolled open-label safety study.

If approved, cytisinicline has the potential to become the first new FDA-approved treatment option in nearly 20 years.

29M

Smokers in the US 1

17M

E-Cigs in the US 2

Nicotine dependence is a serious medical issue that demands a medical solution

The harms associated with smoking are well established, increasing the risk of COPD, cardiovascular disease, cancer, and other serious conditions.

While over half attempt to quit smoking each year, fewer than 10% succeed.1 The toll is staggering – lost lives and over $300 billion in annual smoking-related healthcare costs.3

A more effective treatment is critical to addressing this widespread public health crisis.

8M

Worldwide Deaths Annually4

16M

Americans Live with Smoking- Related Disease5

Introducing

Cytisinicline

demonstrated in clinical trials to provide favorable odds of quitting6,7

focused on precision targeting of nicotine receptors

In two recent trials, cytisinicline has been shown to effectively help even highly dependent smokers stop smoking.6,7 Cytisinicline binds to the same receptors as nicotine to reduce both withdrawal symptoms and satisfaction associated with smoking.8 And since it doesn’t bind as strongly to certain receptors, it is believed to have less potential to cause side effects — including nausea and vomiting.

Smoking cessation phase 3 trial results

vaping cessation phase 2 trial results

cytisinicline development program

Latest News

 

Achieve Life Sciences Announces Closing of Public Offering of Common Stock and Partial Exercise of Underwriters’ Option to Purchase Additional Securities

SEATTLE, Wash. and VANCOUVER, British Columbia, June 30, 2025 — Achieve Life Sciences, Inc. (Nasdaq: ACHV), a late

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Achieve Life Sciences Announces Pricing of $45.0 Million Underwritten Public Offering

SEATTLE, Wash. and VANCOUVER, British Columbia, June 26, 2025 — Achieve Life Sciences, Inc. (Nasdaq: ACHV), a late

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Achieve Life Sciences Announces Proposed Underwritten Public Offering

SEATTLE, Wash. and VANCOUVER, British Columbia, June 26, 2025 – Achieve Life Sciences, Inc. (Nasdaq: ACHV), a late-sta

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Achieve Life Sciences Announces Partnership with Omnicom to Execute Integrated, Data-Driven Launch of the First Potential New Treatment for Nicotine Dependence in Nearly Two Decades

Omnicom cross-agency collaboration to drive technology-led, innovative launch strategy  Partnership brings together pro

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WE CAN’T HELP BUT
BELIEVE

And we’re looking for others, like us, who believe we can bring an end to this fight. Will you join us?

  • US Headquarters
  • 22722 29th Dr SE, Suite 100
  • Bothell, WA 98021
  • Phone: (425) 686-1500
  • Vancouver Office
  • 1040 W Georgia Street, Suite 1030
  • Vancouver, BC V6E 4H1